In this study, we combined the specificity of monoclonal antibody labeling for protein-bound glutathione (GS-Pro) with the ability of confocal microscopy to localize molecules with high spatial resolution. We performed immunofluorescence analysis on dermal fibroblasts, both in steady state than in proliferative conditions, and on in situ extracted matrix samples.
Over the last two decades, there has been an increasing awareness regarding the potential impact of indoor air pollution on human health.
ConclusionsThis work reports in detail the interactions between HMSC and HDMEC in a long‐term co‐culture 2D system.
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We present the case of a 30-year-old woman with history of tonic-clonic seizures who developed a generalized, erythematous, morbilliform skin eruption along with oral and ocular ulcerations 4 months into treatment with lamotrigine. Skin examination was remarkable for confluent and discrete bright red, flat-topped papules on her trunk, extremities, face, neck, palms, and soles over a background of vascular hyperemia. Mucosal surfaces presented multiple ill-defined superficial erosions and ulcerations over her lips extending onto the oral commissures
Aesthetic Rejuvenation: A Regional Approach edited by Ranell Hirsch, Neil Sadick, and Joel L.
To the Editor: A 32-year-old woman with acute myelogenous leukemia presented with a 2-month history of subtle papules on her cheeks and forehead 100 days after allogenic bone-marrow transplantation (). She was on cyclosporine for graft-versus-host disease prophylaxis. A punch biopsy specimen from her cheek revealed a dermal folliculocentric infiltrate with exocytosis of atypical lymphocytes into the follicular epithelium and mucin deposition (, A)
Conclusions: Constitutive activation of c‐Abl/PKC‐δ/Fli1 pathway at least partially contributes to the establishment of pro‐fibrotic phenotype in LSc dermal fibroblasts, which provides a novel molecular basis to explain the efficacy of imatinib against skin sclerosis in a certain subset of LSc.
KH BasavarajIndian Journal of Dermatology 2012 57(3):169-174Nanotechnology and nanomedicine are complementary disciplines aimed at the betterment of human life. Nanotechnology is an emerging branch of science for designing tools and devices of size 1-100 nm, with unique functions at the cellular, atomic and molecular levels
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