Posts Tagged ‘abstract’
Anti-aging effects of high molecular weight proteoglycan from salmon nasal cartilage in hairless mice.
1, May 2012Authors: Goto M, Yamazaki S, Kato Y, Yamamoto K, Katagata Y Abstract Proteoglycans comprise a family of complex macromolecules consisting of a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin anti-aging effects of oral administration of proteoglycan fractions with different molecular weights from salmon nasal cartilage were investigated in a hairless mouse model of skin aging; aging was caused by repeated ultraviolet B (UVB) irradiation. Three proteoglycan fractions of different molecular weights were prepared from salmon nasal cartilage water extract by ion-exchange column chromatography and gel filtration column chromatography.
Tuning the Properties of Elastin Mimetic Hybrid Copolymers via a Modular Polymerization Method.
26, Apr 2012Authors: Grieshaber SE, Farran AJ, Bai S, Kiick KL, Jia X Abstract We have synthesized elastin mimetic hybrid polymers (EMHPs) via the step-growth polymerization of azide-functionalized poly(ethylene glycol) (PEG) and alkyne-terminated peptide (AKAAAKA)2 (AK2) that is abundant in the crosslinking domains of the natural elastin. The modular nature of our synthesis allows facile adjustment of the peptide sequence to modulate the structural and biological properties of EMHPs
Authors: Kitano T, Yoda H, Tabata K, Miura M, Toriyama M, Motohashi S, Suzuki T Abstract We investigated the cytotoxicity of eight vitamin K3 (VK3) analogs against neuroblastoma cell lines (IMR-32, LA-N-1, NB-39, and SK-N-SH) and normal cell lines (human umbilical vein endothelial cells (HUVEC) and human dermal fibroblasts (HDF)) using a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naphthoquinone (VK3-OCH(3)) showed especially potent cytotoxic activities against neuroblastoma cells compared with normal cells.
NLRC5 Controls Basal MHC Class I Gene Expression in an MHC Enhanceosome-Dependent Manner.
6, Apr 2012Authors: Neerincx A, Rodriguez GM, Steimle V, Kufer TA Abstract Nucleotide-binding domain and leucine-rich repeat (NLR) proteins play important roles in innate immune responses as pattern-recognition receptors. Although most NLR proteins act in cell autonomous immune pathways, some do not function as classical pattern-recognition receptors.
Authors: Mu H, Calderone TL, Davies MA, Prieto V, Wang H, Mills GB, Bar-Eli M, Gershenwald JE Abstract The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) are aberrantly expressed in many types of human cancer. LPA has been reported to induce tumor cell proliferation, migration, and cytokine production
- In: Health News
- Tags: abstract, calderone, davies, gershenwald, human-dermal, induce-tumor, induces-cell, lpa, mills, prieto
Authors: Ansurudeen I, Sunkari VG, Grünler J, Peters V, Schmitt CP, Catrina SB, Brismar K, Forsberg EA Abstract Diabetes mellitus (DM) is a progressive disorder with severe late complications. Normal wound healing involves a series of complex and well-orchestrated molecular events dictated by multiple factors. In diabetes, wound healing is grossly impaired due to defective, and dysregulated cellular and molecular events at all phases of wound healing resulting in chronic wounds that fail to heal
- In: Health News
- Tags: abstract, all-phases, ansurudeen, brismar, catrina, chronic-wounds, effect, forsberg, schmitt, severe-late, sunkari, wound-healing
Authors: Yoshioka D, Ishii H, Uchida T, Fujiwara S, Umeki K, Sakamoto N, Kadota J Abstract Bullous pemphigoid, the most common autoimmune blistering disease, is characterized by an autoimmune response to a component of hemidesmosomes within the dermal-epidermal junction. Immunofluorescence examination of skin biopsies demonstrates linear deposition of IgG and C3 in the basement membrane zone. A 73-year-old woman was admitted to our institution because of interstitial lung disease with persistent dry cough, dyspnea on exertion, and bullous eruptions on the skin of her trunk and extremities
- In: Health News
- Tags: abstract, basement, dermal, fujiwara, her-trunk, institution, lung-biopsy, lung-disease, our-institution, sakamoto, skin, the-basement, trunk, yoshioka
This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process. Biochem Cell Biol. 2012 Feb 14; Authors: Ishii N, Kobayashi T, Matsumiya K, Ryu M, Hirata Y, Matsumura Y, Suzuki YA Abstract Lactoferrin (Lf), a multifunctional glycoprotein, is known to activate dermal fibroblasts.
- In: Health News
- Tags: abstract, activate-dermal, activity, article, biochem-cell, dermal, effect, efficiency, form-assemblies, journal, kobayashi, lactoferrin, matsumura, transdermal
Authors: Barradas AM, Fernandes HA, Groen N, Chai YC, Schrooten J, van de Peppel J, van Leeuwen JP, van Blitterswijk CA, de Boer J Abstract The response of osteoprogenitors to calcium (Ca(2+)) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca(2+) released from these ceramic materials influences cells in situ
- In: Health News
- Tags: abstract, blitterswijk, currently-not, known-how, latter-makes, normal-bone, response, the-expression
Authors: Moon H, Yong H, Lee AR Abstract To evaluate a potential anti-scar therapy, we first need to have a reliable in vitro wound model to understand dermal fibroblast response upon cell injury and how cytokine levels are changed upon different wound heal phases. An in vitro wound model with different scratch assay conditions on primary human foreskin fibroblast monolayer cultures was prepared and cytokine levels and growth properties were evaluated with the aim of determining optimum injury conditions and observation time. Morphological characteristics of differently scratched fibroblasts from 0 to 36 h post injury (1 line, 2 lines and 3 lines) were investigated.
