Posts Tagged ‘british’

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Constitutive activation of c‐Abl/protein kinase C‐δ/Fli1 pathway in dermal fibroblasts derived from patients with localized scleroderma

16, May 2012

Conclusions:  Constitutive activation of c‐Abl/PKC‐δ/Fli1 pathway at least partially contributes to the establishment of pro‐fibrotic phenotype in LSc dermal fibroblasts, which provides a novel molecular basis to explain the efficacy of imatinib against skin sclerosis in a certain subset of LSc.

Interleukin‐18 system plays an important role in keloid pathogenesis via epithelial–mesenchymal interactions

14, May 2012

Conclusions  The present study has proven that the IL‐18 system plays an important role in keloid pathogenesis via epithelial–mesenchymal interactions. It also suggests a therapeutic potential of PI3K, MAPK, Sp1 and mTOR inhibitors in the treatment of keloid scarring

Topical application of disodium isostearyl 2‐O‐L‐ascorbyl phosphate, an amphiphilic ascorbic acid derivative, reduces neuropathic hyperalgesia…

8, May 2012

CONCLUSIONS AND IMPLICATIONSAscorbic acid, known to inhibit Cav3.2 channels, suppressed neuropathic hyperalgesia. DI‐VCP ointment for topical application may be of benefit in the treatment of neuropathic pain.

Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells…

23, Apr 2012

Conclusions  These results suggest that androgens deregulate DPC‐secreted factors involved in normal HF stem cell differentiation via the inhibition of the canonical Wnt signalling pathway.

Aquagenic (pseudo)keratoderma: A clinical series with new pathological insights

18, Apr 2012

Conclusions  Aquagenic keratoderma may be associated with a heterozygous mutation in the cystic fibrosis gene. Although the diagnosis is a clinical one, histopathology is useful and may reveal some characteristic diagnostic clues

Excised melanocytic lesions in children and adolescents: A ten‐year survey.

19, Mar 2012

Conclusions:  The overall NNE value in pediatric patients over the 10‐year study period was 593,8, meaning that about 594 lesions were excised to find 1 melanoma. This value is 20 times higher than the rates found in adult patients

Excised melanocytic lesions in children and adolescents: A ten-year survey.

19, Mar 2012

Conclusions:  The overall NNE value in pediatric patients over the 10-year study period was 593,8, meaning that about 594 lesions were excised to find 1 melanoma. This value is 20 times higher than the rates found in adult patients

FGFR3, PIK3CA and RAS mutations in benign lichenoid keratosis

14, Mar 2012

Conclusions  Our results indicate that FGFR3, PIK3CA and RAS mutations are present in approximately 50% of BLKs. These findings support the concept on the molecular genetic level that at least a proportion of BLKs represents regressive variants resulting from former benign epidermal tumours such as seborrhoeic keratosis and solar lentigo.

Acquired bilateral melanosis of the neck in perimenopausal women

23, Feb 2012

Conclusions  These cases seem to represent a continuum of Riehl melanosis. However, the principal distribution of the pigmentation is a distinguishing feature.

Hair follicle stem cell differentiation is inhibited through a cross talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells…

27, Jan 2012

Conclusions:  These results suggest that androgens deregulate DPC‐secreted factors involved in normal HF stem cell differentiation via the inhibition of the canonical Wnt signalling pathway.


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