ConclusionAP‐1 is up‐regulated in a TGFβ‐dependent manner in SSc. The selective AP‐1 inhibitor T‐5224 reduced collagen synthesis selectively in SSc fibroblasts and efficiently prevented the development of experimental dermal fibrosis. Thus, AP‐1 might be a promising new molecular target for the treatment of SSc.
With more physicians performing injections to the face in increasingly sophisticated ways, techniques must evolve accordingly. Injectables are no longer mere wrinkle fillers but true panfacial volumizers that are placed in many different planes and tissues of the face, in contrast to fillers of the past used for the dermis
Authors: Ouji Y, Ishizaka S, Yoshikawa M Abstract Dermal papilla (DP) cells are associated with the development of hair follicles (HFs) and regulation of the hair cycle. However, primary DP cells prepared from cultured HFs are known to lose their ability to induce HF after culturing in standard media, e.g., fibroblast growth conditions. We explored a new culture condition by which DP cells maintained their HF induction ability.
Conclusion CCL18 mRNA is up‐regulated in CTCL lesional skin, and serum CCL18 levels are significantly increased and correlated with the severity of CTCL. These results suggest that CCL18 may be associated with the development of CTCL
Stem Cells and Development , Vol. 0, No
This study provides interesting insights in injury induced changes in chromatophores in fish.
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