Posts Tagged ‘epidermis’
Primary cutaneous neuroendocrine carcinoma, also known as Merkel cell carcinoma (MCC), usually presents as a dermal and/or subcutaneous tumor. Rarely, it is confined to the epidermis or adnexal epithelium [MCC in situ (MCCIS)].
Chronic wounds – is cellular ‘reception’ at fault? Examining integrins and intracellular signalling
11, Apr 2012As with all physiologic processes, chronic wounds are associated with unique intracellular and cellular/extracellular matrix (ECM) receptor types and signalling messages.
Epithelial-mesenchymal interaction during UVB-induced up-regulation of neutral endopeptidase.
1, Apr 2012Authors: Nakajima H, Ezaki Y, Nagai T, Yoshioka R, Imokawa G Abstract We recently reported that overexpression of the elastase NEP (neutral endopeptidase) by fibroblasts plays a pivotal role in the mechanism of UVB-induced skin wrinkling by degrading dermal elastic fibres. Since UVB does not penetrate to the dermis, we hypothesized that factors secreted by UVB-exposed keratinocytes in the epidermis trigger fibroblasts in the dermis to increase their expression of NEP which then degrades the elastic fibres. In the present study, we characterized the epithelial-mesenchymal interaction between keratinocytes and fibroblasts which leads to increased expression of NEP
- In: Health News
- Tags: dermis, elastase, epidermis, express, expression, mechanism, present, skin-wrinkling, the-epidermis
Histomorphometric Analysis and Regional Variations of Full Thickness Skin Grafts in Dogs
1, Apr 2012ConclusionsThickness of the epidermis and dermis is dependent on body region. Hair follicle density in the FTSG specimens was decreased compared with intact skin specimens, which may affect hair regrowth in FTSG. (Source: Veterinary Surgery)
Oral administration of collagen tripeptide improves dryness and pruritus in the acetone-induced dry skin model
14, Mar 2012Conclusion: Oral administration of CTP improves dry skin and normalizes axon-guidance factors in the epidermis in addition to reducing pruritus. CTP may be used in a new therapeutic strategy against dry skin and pruritus. (Source: Journal of Dermatological Science)
Chronic ethanol (EtOH) feeding induces subset loss and hypo-responsiveness in multiple skin T cell populations
17, Feb 2012Alcoholism is associated with cutaneous immune deficiency and while the basis for this is largely unknown, the sensitivity of skin immune cells to EtOH has been clearly demonstrated. Murine models of alcoholism have shown that EtOH reduces skin dendritic cell (DC) numbers and compromises their migratory capacity following skin sensitization.
Protective Effects of Pine Bark Extract on Hexavalent Chromium‐Induced Dermatotoxicity in Rats
17, Feb 2012The present study investigated the protective effects of pine bark extract (PBE) against hexavalent chromium [Cr(VI)]‐induced dermatotoxicity in rats. Skin reactions were evaluated by visual inspection, histopathological changes and oxidative stress parameters. Topical application of Cr(VI) produced a significant increase in the incidence and severity of erythema and edema upon visual inspection.
- In: Health News
- Tags: contrary, dermis, epidermis, incidence, protective, reactions-were, severe-necrosis, showed-moderate, skin, the-incidence
Epidermogenesis in a skin wound deep through the basement membrane contributes to scar formation
3, Feb 2012In normal human skin, the basement membrane (BM) lies between the epidermis and dermis, connecting the two compartments tightly and keeping them from direct contact. During skin wound healing, fibroblasts from adjacent intact dermis are activated and migrate to fibrin clots to form granulation tissue, onto which activated keratinocytes at the wound margin migrate, stratify, and differentiate to form a new integument; however, a well-developed BM is not observed until a few months later . During this period, homeostasis between the epidermal and dermal compartments is interrupted and abnormal epidermal–dermal events can ensue
The objective of our work was to identify RCM parameters able to quantify in vivo dermis papilla density and epidermis pigmentation potentially applicable in clinical studies. The study included 111 healthy female volunteers with phototype I to VI
This study reveals that not only do adult (M ≥ 525 mm, F ≥ 550 mm) S. canicula show a sexual dimorphism in the epidermis and dermis, but that hatchling S. canicula are born with a sexually dimorphic epidermal layer and this persists into the juvenile stage (M
