Posts Tagged ‘study’
In this study, we combined the specificity of monoclonal antibody labeling for protein-bound glutathione (GS-Pro) with the ability of confocal microscopy to localize molecules with high spatial resolution. We performed immunofluorescence analysis on dermal fibroblasts, both in steady state than in proliferative conditions, and on in situ extracted matrix samples.
- In: Health News
- Tags: ability, cells-reach, nuclear-lamina, nuclear-shift, situ-extracted, specificity, steady-state, study, the-first
This study showed that this photosensitiser, hypericin, was taken up by the cells in a concentration-dependent manner over 24
This study suggests that the modified composites increase antimicrobial properties while basic composite characteristics are not influenced by the filler. (Source: Dental Materials)
Nanocomposite containing CaF2 nanoparticles: Thermal cycling, wear and long-term water-aging
8, May 2012The objectives of this study were to develop nanocomposite containing calcium fluoride nanoparticles (nCaF2), and to investigate the long-term mechanical durability including wear, thermal-cycling and long-term water-aging behavior.Methods: Two types of fillers were used: nCaF2 with a diameter of 53nm, and glass particles of 1.4μm. Four composites were fabricated with fillers of: (1) 0% nCaF2+65% glass; (2) 10% nCaF2+55% glass; (3) 20% nCaF2+45% glass; (4) 30% nCaF2+35% glass. Three commercial materials were also tested.
The objective of this study was to investigate the physical characteristics of poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) coated with two surfactants, Pluronic or the commonly used polyvinyl alcohol (PVA); and determine their in vitro efficiency as drug carriers for cancer therapy. Free surfactant cytotoxicity results indicated that Pluronic F127 (PF127) was most cytocompatible among the Pluronics tested and hence chosen for coating PLGA NPs for further studies.
- In: Health News
- Tags: aortic-smooth, commonly, drug-carriers, human-dermal, physical, plga, pluronic, studies, study, two-surfactants
In this study, GOIC film and collagen film (CF) are used as dressing material on the wound of streptozotocin-induced diabetic rats. A significant increase in ROS (p < 0.05) was observed in the fibroblast of GOIC group during the inflammation period compared to the CF and control groups. This elevated level up regulated the antioxidant status in the granulation tissue and improved cellular proliferation in the GOIC group.
Conclusion.We demonstrated that JAK2 is activated in a TGFβ dependent manner in SSc.
ConclusionThis study is the first to show that topo I binds specifically to HS proteoglycans on fibroblast surfaces and that anti–topo I autoantibodies from SSc patients amplify topo I binding to HS chains. The accumulation of topo I on cell surfaces by anti–topo I autoantibodies could contribute to the initiation of an inflammatory cascade stimulating the fibrosis. UFH and LMWH inhibited the binding of topo I/anti–topo I IC to fibroblasts, suggesting a potential therapeutic role in SSc‐associated fibrosis.
