Abstract
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(Source: Journal of Surgical Research)
Conclusions: These data suggest that TLR2 and TLR4 have unique effects on EC behavior. TLR4 antagonism results in EC proliferation, supporting the improved angiogenic response to HLI in TLR4KO mice. Alternatively,TLR2 antagonism results in truncated tube formation
Conclusions: We have generated a novel transgenic model enabling temporal and cell-specific control of SDF-1α deletion. As expected, recruitment of progenitor cells to sites of ischemic injury is reduced when cells fail to express SDF-1α and results in impaired wound healing. Knockout of SDF-1α expression from endothelial cells alone however, is not sufficient to elicit a change in phenotype
(Source: Journal of Surgical Research)
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