Posts Tagged ‘the-first’
In this study, we combined the specificity of monoclonal antibody labeling for protein-bound glutathione (GS-Pro) with the ability of confocal microscopy to localize molecules with high spatial resolution. We performed immunofluorescence analysis on dermal fibroblasts, both in steady state than in proliferative conditions, and on in situ extracted matrix samples.
- In: Health News
- Tags: ability, cells-reach, nuclear-lamina, nuclear-shift, situ-extracted, specificity, steady-state, study, the-first
ConclusionThis study is the first to show that topo I binds specifically to HS proteoglycans on fibroblast surfaces and that anti–topo I autoantibodies from SSc patients amplify topo I binding to HS chains. The accumulation of topo I on cell surfaces by anti–topo I autoantibodies could contribute to the initiation of an inflammatory cascade stimulating the fibrosis. UFH and LMWH inhibited the binding of topo I/anti–topo I IC to fibroblasts, suggesting a potential therapeutic role in SSc‐associated fibrosis.
In conclusion, this study describes for the first time an interaction between SPARC and SFN that may have implications for the regulation of matrix deposition and prevention of dermal fibrotic conditions such as hypertrophic scars and keloid. J
Conclusion: This study provides the first insight into the complex nature of the UBM and how its application may be tailored for specific applications in regenerative medicine.
We report the first case of multiple branchial cleft anomalies with a peripheral dermal sinus of the ipsilateral lower extremity. Numerous concurrent congenital anomalies exist in the patient, representing the first description of the Guarisco–Winters syndrome. The patient is intellectually and developmentally age-appropriate in all other regards.
Authors: Gavini A, Telang GH, Olszewski AJ Abstract A 72-year-old woman presented with dyspnea and lower extremity edema.
- In: Health News
- Tags: abstract, olszewski, patient, punch-biopsy, the-first, the-patient, upper-dermal, woman-presented
Why I Got Botox In My 20′s – TheGloss
17, Jan 2012TheGloss Why I Got Botox In My 20′s TheGloss He suggested we fill them in with Radiesse , an injectable filler.
- In: Health News
- Tags: botox, certainly-didn, much-longer, nor-did, table-border, the-first, years-later
